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谷口俊介

私たちの研究室では、ウニの胚・幼生を用いて、発生過程における体軸の形成と神経の形成の仕組みを明らかにしています。また、神経細胞が幼生の体の動きや維持に関してどのような機能を担っているのかに関しても研究を行なっています。これらの研究を通して、三次元空間であるこの地球上に我々のような生命体がどのように適応してきたのか、また、その過程に神経という存在がどのような役割を果たしてきたのかについて理解を深めようとしています。

色素合成を担う遺伝子Pks1をノックアウトしたハリサンショウウニのアルビノ（右下）
色素合成を担う遺伝子Pks1をノックアウトしたハリサンショウウニのアルビノ（右下）
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発表論文

2026

  1. Tsuyuzaki K., Yaguchi J., Yamamoto T., Ikeo K. & Yaguchi S. (2026). Single-cell transcriptomic resources for tracing neurogenesis and cell fate specification in sea urchin embryos. Development, 153(4), dev205025.
  2. Yaguchi S. (2026). Emergence of a Central Nervous System: A Two-Step Evolutionary Model Suggested by Sea Urchin Experiments. Zoological Science, 43(1).

2025

  1. Suzuki H., Yaguchi J., Tsuyuzaki K. & Yaguchi S. (2025). Unraveling the regulative development and molecular mechanisms of identical sea urchin twins. Nature Communications, 16(1), 8005.
  2. Yaguchi S. (2025). Meeting report: Society for Developmental Biology 83rd annual meeting. Development, Growth & Differentiation, 67(1), 6-9.
  3. Yaguchi J., Tsuyuzaki K., Sawada I., Horiuchi A., Sakamoto N., Yamamoto T., Yamashita T. & Yaguchi S. (2025). Non-visual photoreceptive brain specification in sea urchin larvae. Nature Communications, 16(1), 10054.

2024

  1. Komoto T., Ikeo K., Yaguchi S., Yamamoto T., Sakamoto N. & Awazu A. (2024). Assembly of continuous high‐resolution draft genome sequence of Hemicentrotus pulcherrimus using long‐read sequencing. Development, Growth & Differentiation, 66(4), 297-304.
  2. Yaguchi J., Sakai K., Horiuchi A., Yamamoto T., Yamashita T. & Yaguchi S. (2024). Light-modulated neural control of sphincter regulation in the evolution of through-gut. Nature Communications, 15(1), 8881.

2023

  1. Kamata M., Taniguchi Y., Yaguchi J., Tanaka H. & Yaguchi S. (2023). Nonmuscular Troponin‐I is required for gastrulation in sea urchin embryos. Developmental Dynamics, dvdy.680.
  2. Yaguchi S. & Yaguchi J. (2023). Development and function of nervous systems of sea urchin larvae. Hikaku seiri seikagaku(Comparative Physiology and Biochemistry), 40(3), 137-148.
  3. Yaguchi J. & Yaguchi S. (2023). Rx and its downstream factor, Musashi1, is required for establishment of the apical organ in sea urchin larvae. Frontiers in Cell and Developmental Biology, 11, 1240767.

2022

  1. Kinjo S., Kiyomoto M., Suzuki H., Yamamoto T., Ikeo K. & Yaguchi S. (2022). TrBase: A genome and transcriptome database of Temnopleurus reevesii. Development, Growth & Differentiation, 64(4), 210-218.
  2. Suzuki H. & Yaguchi S. (2022). Direct TGF ‐ß signaling via alk4/5/7 pathway is involved in gut bending in sea urchin embryos. Developmental Dynamics, 251(1), 226-234.
  3. Yaguchi S. & Yaguchi J. (2022). Temnopleurus reevesii as a new sea urchin model in genetics. Development, Growth & Differentiation, dgd.12768.
  4. Yaguchi S. & Wada H. (2022). Marine genomics, transcriptomics, and beyond in developmental, cell, and evolutionary biology. Development, Growth & Differentiation, 64(4), 196-197.
  5. Yaguchi S., Taniguchi Y., Suzuki H., Kamata M. & Yaguchi J. (2022). Planktonic sea urchin larvae change their swimming direction in response to strong photoirradiation. PLOS Genetics, 18(2), e1010033.

2021

  1. Formery L., Orange F., Formery A., Yaguchi S., Lowe C.J., Schubert M. & Croce J.C. (2021). Neural anatomy of echinoid early juveniles and comparison of nervous system organization in echinoderms. Journal of Comparative Neurology, 529(6), 1135-1156.
  2. Kinjo S., Kiyomoto M., Yamamoto T., Ikeo K. & Yaguchi S. (2021). Usage of the Sea Urchin Hemicentrotus pulcherrimus Database, HpBase. In Carroll D.J. & Stricker S.A. (Eds.), Developmental Biology of the Sea Urchin and Other Marine Invertebrates (pp. 267-275). New York, NY: Springer US.
  3. Kiyozumi D., Yaguchi S., Yaguchi J., Yamazaki A. & Sekiguchi K. (2021). Human disease-associated extracellular matrix orthologs ECM3 and QBRICK regulate primary mesenchymal cell migration in sea urchin embryos. Experimental Animals, 70(3), 378-386.
  4. Yaguchi S. (2021). Echinoderms: Temnopleurus reevesii. In Boutet A. & Schierwater B. (Eds.), Handbook of Marine Model Organisms in Experimental Biology: Established and Emerging. Boca Raton: CRC Press.
  5. Yaguchi J. & Yaguchi S. (2021). Sea urchin larvae utilize light for regulating the pyloric opening. BMC Biology, 19(1), 64.

2020

  1. Yaguchi S., Morino Y. & Sasakura Y. (2020). Development of Marine Invertebrates. In Inaba K. & Hall-Spencer J.M. (Eds.), Japanese Marine Life (pp. 109-124). Singapore: Springer Singapore.
  2. Yaguchi S., Yaguchi J., Suzuki H., Kinjo S., Kiyomoto M., Ikeo K. & Yamamoto T. (2020). Establishment of homozygous knock-out sea urchins. Current Biology, 30(10), R427-R429.

2019

  1. Burke R.D. & Yaguchi S. (2019). Analysis of neural activity with fluorescent protein biosensors. In Methods in Cell Biology (pp. 519-526). Elsevier.
  2. Erkenbrack E.M., Croce J.C., Miranda E., Gautam S., Martinez-Bartolome M., Yaguchi S. & Range R.C. (2019). Whole mount in situ hybridization techniques for analysis of the spatial distribution of mRNAs in sea urchin embryos and early larvae. In Methods in Cell Biology (pp. 177-196). Elsevier.
  3. Yaguchi S. (2019). Temnopleurus as an emerging echinoderm model. In Methods in Cell Biology (pp. 71-79). Elsevier.
  4. Yaguchi J. & Yaguchi S. (2019). Evolution of nitric oxide regulation of gut function. Proceedings of the National Academy of Sciences, 116(12), 5607-5612.
  5. Yaguchi J. (2019). Microinjection methods for sea urchin eggs and blastomeres. In Methods in Cell Biology (pp. 173-188). Elsevier.
  6. Yamazaki A., Yamamoto A., Yaguchi J. & Yaguchi S. (2019). cis ‐Regulatory analysis for later phase of anterior neuroectoderm‐specific foxQ2 expression in sea urchin embryos. genesis, e23302.

2018

  1. Kinjo S., Kiyomoto M., Yamamoto T., Ikeo K. & Yaguchi S. (2018). HpBase: A genome database of a sea urchin, Hemicentrotus pulcherrimus. Development, Growth & Differentiation, 60(3), 174-182.
  2. Suzuki H. & Yaguchi S. (2018). Transforming growth factor-β signal regulates gut bending in the sea urchin embryo. Development, Growth & Differentiation, 60(4), 216-225.
  3. Yaguchi J., Yamazaki A. & Yaguchi S. (2018). Meis transcription factor maintains the neurogenic ectoderm and regulates the anterior-posterior patterning in embryos of a sea urchin, Hemicentrotus pulcherrimus. Developmental Biology, 444(1), 1-8.

2017

  1. Mizuno K., Shiba K., Yaguchi J., Shibata D., Yaguchi S., Prulière G., Chenevert J. & Inaba K. (2017). Calaxin establishes basal body orientation and coordinates movement of monocilia in sea urchin embryos. Scientific Reports, 7(1), 10751.
  2. Yaguchi S., Yaguchi J. & Tanaka H. (2017). Troponin-I is present as an essential component of muscles in echinoderm larvae. Scientific Reports, 7(1), 43563.

2016

  1. Yaguchi J., Takeda N., Inaba K. & Yaguchi S. (2016). Cooperative Wnt-Nodal Signals Regulate the Patterning of Anterior Neuroectoderm. PLOS Genetics, 12(4), e1006001.

2015

  1. Yaguchi S., Yaguchi J. & Inaba K. (2015). Bicaudal-C is required for the formation of anterior neurogenic ectoderm in the sea urchin embryo. Scientific Reports, 4(1), 6852.
  2. Yaguchi S., Yamazaki A., Wada W., Tsuchiya Y., Sato T., Shinagawa H., Yamada Y. & Yaguchi J. (2015). Early development and neurogenesis of Temnopleurus reevesii. Development, Growth & Differentiation, 57(3), 242-250.

2014

  1. Krupke O., Yaguchi S., Yaguchi J. & Burke R.D. (2014). Imaging Neural Development in Embryonic and Larval Sea Urchins. In Carroll D.J. & Stricker S.A. (Eds.), Developmental Biology of the Sea Urchin and Other Marine Invertebrates (pp. 147-160). Totowa, NJ: Humana Press.

2013

  1. Jin Y., Yaguchi S., Shiba K., Yamada L., Yaguchi J., Shibata D., Sawada H. & Inaba K. (2013). Glutathione transferase theta in apical ciliary tuft regulates mechanical reception and swimming behavior of Sea Urchin Embryos. Cytoskeleton, 70(8), 453-470.

2012

  1. Yaguchi J., Angerer L.M., Inaba K. & Yaguchi S. (2012). Zinc finger homeobox is required for the differentiation of serotonergic neurons in the sea urchin embryo. Developmental Biology, 363(1), 74-83.

2011

  1. Angerer L.M., Yaguchi S., Angerer R.C. & Burke R.D. (2011). The evolution of nervous system patterning: insights from sea urchin development. Development, 138(17), 3613-3623.
  2. Endo T., Ueno K., Yonezawa K., Mineta K., Hotta K., Satou Y., Yamada L., Ogasawara M., Takahashi H., Nakajima A., Nakachi M., Nomura M., Yaguchi J., Sasakura Y., Yamasaki C., Sera M., Yoshizawa A.C., Imanishi T., Taniguchi H. & Inaba K. (2011). CIPRO 2.5: Ciona intestinalis protein database, a unique integrated repository of large-scale omics data, bioinformatic analyses and curated annotation, with user rating and reviewing functionality. Nucleic Acids Research, 39(Database), D807-D814.
  3. Yaguchi S., Yaguchi J., Wei Z., Jin Y., Angerer L.M. & Inaba K. (2011). Fez function is required to maintain the size of the animal plate in the sea urchin embryo. Development, 138(19), 4233-4243.
  4. Yoshiyama-Yanagawa T., Enya S., Shimada-Niwa Y., Yaguchi S., Haramoto Y., Matsuya T., Shiomi K., Sasakura Y., Takahashi S., Asashima M., Kataoka H. & Niwa R. (2011). The Conserved Rieske Oxygenase DAF-36/Neverland Is a Novel Cholesterol-metabolizing Enzyme. Journal of Biological Chemistry, 286(29), 25756-25762.

2010

  1. Katow H., Suyemitsu T., Ooka S., Yaguchi J., Jin-nai T., Kuwahara I., Katow T., Yaguchi S. & Abe H. (2010). Development of a dopaminergic system in sea urchin embryos and larvae. Journal of Experimental Biology, 213(16), 2808-2819.
  2. Ooka S., Katow T., Yaguchi S., Yaguchi J. & Katow H. (2010). Spatiotemporal expression pattern of an encephalopsin orthologue of the sea urchin Hemicentrotus pulcherrimus during early development, and its potential role in larval vertical migration: Expression and potential role of Hp-ECPN. Development, Growth & Differentiation, 52(2), 195-207.
  3. Sasakura Y., Yaguchi J., Yaguchi S. & Yajima M. (2010). Excision and Transposition Activity of Tc1/ mariner Superfamily Transposons in Sea Urchin Embryos. Zoological Science, 27(3), 256-262.
  4. Yaguchi S., Yaguchi J., Wei Z., Shiba K., Angerer L.M. & Inaba K. (2010). ankAT-1 is a novel gene mediating the apical tuft formation in the sea urchin embryo. Developmental Biology, 348(1), 67-75.
  5. Yaguchi S., Yaguchi J., Angerer R.C., Angerer L.M. & Burke R.D. (2010). TGFβ signaling positions the ciliary band and patterns neurons in the sea urchin embryo. Developmental Biology, 347(1), 71-81.

2009

  1. Wei Z., Yaguchi J., Yaguchi S., Angerer R.C. & Angerer L.M. (2009). The sea urchin animal pole domain is a Six3-dependent neurogenic patterning center. Development, 136(7), 1179-1189.

2008

  1. Yaguchi S., Yaguchi J., Angerer R.C. & Angerer L.M. (2008). A Wnt-FoxQ2-Nodal Pathway Links Primary and Secondary Axis Specification in Sea Urchin Embryos. Developmental Cell, 14(1), 97-107.

2007

  1. Katow H., Yaguchi S. & Kyozuka K. (2007). Serotonin stimulates [Ca2+]i elevation in ciliary ectodermal cells of echinoplutei through a serotonin receptor cell network in the blastocoel. Journal of Experimental Biology, 210(3), 403-412.
  2. Poustka A.J., Kühn A., Groth D., Weise V., Yaguchi S., Burke R.D., Herwig R., Lehrach H. & Panopoulou G. (2007). A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks. Genome Biology, 8(5), R85.
  3. Yaguchi S., Yaguchi J. & Burke R.D. (2007). Sp-Smad2/3 mediates patterning of neurogenic ectoderm by nodal in the sea urchin embryo. Developmental Biology, 302(2), 494-503.

2006

  1. Sea Urchin Genome Sequencing Consortium, Sodergren E., Weinstock G.M., Davidson E.H., Cameron R.A., Gibbs R.A., Angerer R.C., Angerer L.M., Arnone M.I., Burgess D.R., Burke R.D., Coffman J.A., Dean M., Elphick M.R., Ettensohn C.A., Foltz K.R., Hamdoun A., Hynes R.O., Klein W.H., Marzluff W., McClay D.R., Morris R.L., Mushegian A., Rast J.P., Smith L.C., Thorndyke M.C., Vacquier V.D., Wessel G.M., Wray G., Zhang L., Elsik C.G., Ermolaeva O., Hlavina W., Hofmann G., Kitts P., Landrum M.J., Mackey A.J., Maglott D., Panopoulou G., Poustka A.J., Pruitt K., Sapojnikov V., Song X., Souvorov A., Solovyev V., Wei Z., Whittaker C.A., Worley K., Durbin K.J., Shen Y., Fedrigo O., Garfield D., Haygood R., Primus A., Satija R., Severson T., Gonzalez-Garay M.L., Jackson A.R., Milosavljevic A., Tong M., Killian C.E., Livingston B.T., Wilt F.H., Adams N., Belle R., Carbonneau S., Cheung R., Cormier P., Cosson B., Croce J., Fernandez-Guerra A., Geneviere A.M., Goel M., Kelkar H., Morales J., Mulner-Lorillon O., Robertson A.J., Goldstone J.V., Cole B., Epel D., Gold B., Hahn M.E., Howard-Ashby M., Scally M., Stegeman J.J., Allgood E.L., Cool J., Judkins K.M., McCafferty S.S., Musante A.M., Obar R.A., Rawson A.P., Rossetti B.J., Gibbons I.R., Hoffman M.P., Leone A., Istrail S., Materna S.C., Samanta M.P., Stolc V., Tongprasit W., Tu Q., Bergeron K.F., Brandhorst B.P., Whittle J., Berney K., Bottjer D.J., Calestani C., Peterson K., Chow E., Yuan Q.A., Elhaik E., Graur D., Reese J.T., Bosdet I., Heesun S., Marra M.A., Schein J., Anderson M.K., Brockton V., Buckley K.M., Cohen A.H., Fugmann S.D., Hibino T., Loza-Coll M., Majeske A.J., Messier C., Nair S.V., Pancer Z., Terwilliger D.P., Agca C., Arboleda E., Chen N., Churcher A.M., Hallbook F., Humphrey G.W., Idris M.M., Kiyama T., Liang S., Mellott D., Mu X., Murray G., Olinski R.P., Raible F., Rowe M., Taylor J.S., Tessmar-Raible K., Wang D., Wilson K.H., Yaguchi S., Gaasterland T., Galindo B.E., Gunaratne H.J., Juliano C., Kinukawa M., Moy G.W., Neill A.T., Nomura M., Raisch M., Reade A., Roux M.M., Song J.L., Su Y.H., Townley I.K., Voronina E., Wong J.L., Amore G., Branno M., Brown E.R., Cavalieri V., Duboc V., Duloquin L., Flytzanis C., Gache C., Lapraz F., Lepage T., Locascio A., Martinez P., Matassi G., Matranga V., Range R., Rizzo F., Rottinger E., Beane W., Bradham C., Byrum C., Glenn T., Hussain S., Manning F.G., Miranda E., Thomason R., Walton K., Wikramanayke A., Wu S.Y., Xu R., Brown C.T., Chen L., Gray R.F., Lee P.Y., Nam J., Oliveri P., Smith J., Muzny D., Bell S., Chacko J., Cree A., Curry S., Davis C., Dinh H., Dugan-Rocha S., Fowler J., Gill R., Hamilton C., Hernandez J., Hines S., Hume J., Jackson L., Jolivet A., Kovar C., Lee S., Lewis L., Miner G., Morgan M., Nazareth L.V., Okwuonu G., Parker D., Pu L.L., Thorn R. & Wright R. (2006). The Genome of the Sea Urchin Strongylocentrotus purpuratus. Science, 314(5801), 941-952.
  2. Burke R.D., Angerer L.M., Elphick M.R., Humphrey G.W., Yaguchi S., Kiyama T., Liang S., Mu X., Agca C., Klein W.H., Brandhorst B.P., Rowe M., Wilson K., Churcher A.M., Taylor J.S., Chen N., Murray G., Wang D., Mellott D., Olinski R., Hallböök F. & Thorndyke M.C. (2006). A genomic view of the sea urchin nervous system. Developmental Biology, 300(1), 434-460.
  3. Burke R.D., Osborne L., Wang D., Murabe N., Yaguchi S. & Nakajima Y. (2006). Neuron-specific expression of a synaptotagmin gene in the sea urchin Strongylocentrotus purpuratus. The Journal of Comparative Neurology, 496(2), 244-251.
  4. Yaguchi S., Nakajima Y., Wang D. & Burke R.D. (2006). Embryonic expression of engrailed in sea urchins. Gene Expression Patterns, 6(5), 566-571.
  5. Yaguchi S., Yaguchi J. & Burke R.D. (2006). Specification of ectoderm restricts the size of the animal plate and patterns neurogenesis in sea urchin embryos. Development, 133(12), 2337-2346.

2004

  1. Katow H., Yaguchi S., Kiyomoto M. & Washio M. (2004). The 5-HT receptor cell is a new member of secondary mesenchyme cell descendants and forms a major blastocoelar network in sea urchin larvae. Mechanisms of Development, 121(4), 325-337.

2003

  1. Yaguchi S. & Katow H. (2003). Expression of tryptophan 5‐hydroxylase gene during sea urchin neurogenesis and role of serotonergic nervous system in larval behavior. Journal of Comparative Neurology, 466(2), 219-229.

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