Chiba Laboratory
PI: Tomoki CHIBA
Director, Professor
chiba.tomoki.fp
(@) u.tsukuba.ac.jp
The proteins in our cells are selectively degraded in a spatiotemporal manner, and such degradation is essential for the regulation of a wide range of cellular events, such as cell cycle progression, stress response, and so on. The major pathway that mediates the selective protein degradation is the Ubiquitin and Proteasome System (UPS). Our laboratory is analyzing the regulatory mechanism of the UPS to understand the physiology of “regulated protein degradation”.
The regulation of selective protein degradation