平成22年度    平成24年度    平成25年度


No.23-20 ヤリイカ精子の受精環境に適応した遊泳能力獲得の研究
   代表研究者: お茶の水女子大学 非常勤講師 広橋教貴

  1. Sperm from Sneaker Male Squids Exhibit Chemotactic Swarming to CO2.
    Noritaka Hirohashi, Luis Alvarez, Kogiku Shiba, Eiji Fujiwara, Yoko Iwata, Tatsuma Mohri, Kazuo Inaba, Kazuyoshi Chiba, Hiroe Ochi, Claudiu T. Supuran, Nico Kotzur, Yasutaka Kakiuchi, U. Benjamin Kaupp, Shoji A. Baba  Current Biology, 23, 1-7, 2013 May 8.

  2. The macroscopic structure of RADA16 peptide hydrogel stimulates monocyte/macrophage differentiation in HL60 cells via cholesterol synthesis.
    Kakiuchi Y, Hirohashi N, Murakami-Murofushi K.   Biochem Biophys Res Commun. 2013 Mar 19.

  3. Respiratory CO2 mediates sperm chemotaxis in squids. In Sexual Reproduction in Animals and Plants (Proceedings). Noritaka Hirohashi, Yoko Iwata, Warwick H. H. Sauer, Yasutaka Kakiuchi (Eds, H Sawada, N Inoue, M Iwano) Springer Japan 2013.

  4. Real-time observations of the mouse sperm acrosome reaction during in vitro fertilization. Jin M, Fujiwara E, Hirohashi N. In Sperm cell Research in the 21st Century: Historical Discoveries to New Horizons. Ed. Morisawa M. Adthree Publishing Co., Ltd. 2012.

  5. 動物の受精 12章軟体動物の受精 出口竜作、岩田容子、広橋教貴 化学同人

  6. 動物の受精 10章棘皮動物の受精 松本緑、新倉啓介、広橋教貴 化学同人


No.23-22 自家不和合性に関わるカルシウムシグナルの解析
   代表研究者: 名古屋大学菅島臨海実験所 特任助教 山田力志

  1. Saito T, Shiba K, Inaba K, Yamada L, Sawada H. Self-incompatibility response induced by calcium increase in sperm of the ascidian Ciona intestinalis. (2012) Proc Natl Acad Sci U S A. 109(11):4158-4162.


No.23-23 亜鉛が海洋微生物生態系に及ぼす影響
   代表研究者: 奈良女子大学理学部 助教 瀬戸繭美

  1. M. Seto, S. Wada, and S. Suzuki (2013) The effect of zinc on aquatic microbial ecosystems and the degradation of dissolved organic matter, Chemosphere, 90(3), 1091 - 1102


No.23-24 重金属濃縮に関するカタユウレイボヤ機能欠失変異体の探索
   代表研究者: 広島大学大学院理学研究科 准教授 植木龍也

  1. T. Ueki, T. Nakagawa, H. Michibata. Metal-binding domains and the metal selectivity of the vanadium(IV)-binding protein VBP-129 in blood plasma. J. Inorg. Biochem., 116, 70-76 (2012).

  2. S. Kume, T. Ueki, H. Matsuoka, M. Hamada, N. Satoh, and H. Michibata. Differential gene regulation by V(IV) and V(V) ions in the branchial sac, intestine, and blood cells of a vanadium-rich ascidian, Ciona intestinalis. Biometals, 1810, 457-464 (2012).

  3. S. Samino, H. Michibata, T. Ueki. Identification of a novel vanadium-binding protein by EST analysis on the most vanadium-rich ascidian, Ascidia gemmata. Mar. Biotechnol., 14, 143-154(2012).
  4. T. Ueki, N. Furuno and H. Michibata. A novel vanadium transporter of the Nramp family expressed at the vacuole of vanadium-accumulating cells of the ascidian Ascidia sydneiensis samea. Biochim Biophys Acta, 1810, 457-464 (2011).

  5. T. Ueki and H. Michibata. Molecular mechanism of the transport and reduction pathway of vanadium in ascidians. Coordination Chemistry Reviews, 255, 2249-2257 (2011).


No.23-25 ナメクジウオの適応生理学的研究
   代表研究者: 東京大学大気海洋研究所 教授 竹井祥郎

  1. Nobata, S., Donald, J. A., Balment, R. J. and Takei, Y. (2011). Potent cardiovascular effects of homologous urotensin II (UII) and UII-related peptide in conscious eels after peripheral and central injections. Am. J. Physiol. 300: R437–R446.

  2. Yuyama, I., Watanabe, T., and Takei, Y. (2011). Profiling differential gene expression of symbiotic and aposymbiotic corals using a high coverage gene expression profiling (HiCEP) analysis. Marine Biotech. 13: 32-40.

  3. Wong, M. K. S., and Takei, Y. (2011). Characterization of a native angiotensin from an anciently diverged serine-protease inhibitor in lamprey. J. Endocrinol. 209: 127–137.

  4. Takei, Y., Inoue, K., Trajanovska, S. and Donald, J. A. (2011). B-type natriuretic peptide (BNP), but not ANP, is the basic cardiac natriuretic peptide in vertebrates. Gen. Comp. Endocrinol. 171: 258-266..

  5. Nobata, S., and Takei, Y. (2011). The area postrema in hindbrain is a central player for regulation of drinking behavior in eels, Anguilla japonica. Am. J. Physiol. 300: R1569–R1577.

  6. Watanabe, T., and Takei, Y. (2011). Molecular physiology and functional morphology of sulfate excretion by the kidney of seawater-adapted eels. J. Exp. Biol. 214: 1783-1790.

  7. Watanabe, T., and Takei, Y. (2011) Environmental factors responsible for switching of the SO42- excretory system in the kidney of seawater eels. Am. J. Physiol. 301: R402-R411.

  8. Hu, G.-B., Kusakabe, M., and Takei, Y. (2011). Localization of diversified relaxin gene transcripts in the brain of eels. Gen. Comp. Endocrinol. 172: 430-439.

  9. Inoue, H., Miyanishi, H., Nobata, S., and Takei, Y. (2011). Evolutionary implication of the absence of atrial natriuretic peptide (ANP) in euryhaline Oryzias fishes. Environ. Biol. Fish. DOI 10.1007/s10641-011-9852-9.

  10. Ventura, A., Kusakabe, M., and Takei, Y. (2011). Distinct natriuretic peptides interact with ACTH for cortisol secretion from interrenal tissue of eels in different salinities. Gen. Comp. Endocrinol. 173: 129-138.

  11. Kuwasako, K., Kitamura, K., Nagata, S., Hikosaka, T., Takei, Y., and Kato, J. (2011). Shared and separate functions of the RAMP-based adrenomedullin receptors. Peptides 32: 1540-1550.

  12. Miyanishi, H., Nobata, S., and Takei, Y. (2011). Relative dipsogenic potencies of six natriuretic peptides in eels. Zool. Sci. 28: 719-726.

  13. Tse, K. F. W., Lai, K. P., and Takei, Y. (2011). Medaka Osmotic stress transcription factor 1b (Ostf1b/TSC22D3-2) triggers hyperosmotic responses of different ion transporters in medaka gill and human embryonic kidney cells via the JNK signaling pathway. Int. J. Biochem. Cell. Biol. 43: 1764-1775.

  14. Takei, Y., Bartolo, R. C., Fujihara, H., Ueta, Y., and Donald, J. A., (2012). Water deprivation induces appetite and alters metabolic strategy in Notomys alexis: unique mechanisms for water production in the desert. Proceedings B doi:10.1098/rspb.2011.2627.

  15. Wong, M. K. S., Sower, S. A., and Takei, Y. (2012). The presence of teleost-type angiotensin components in lamprey buccal gland suggests a role in endocrine mimicry. Biochemie 94: 637-648

  16. 竹井祥郎(2011)。海から陸へ:生命進化とナトリウム利尿ペプチド。Modern Physician 31: 679-683..


No.23-34 動植物に共通した受精メカニズムの研究
   代表研究者: 国立成育医療研究センター 室長 宮戸健二

  1. Miyado M, Nakamura M, Miyado K, Morohashi K, Fukami M, Ogata T. Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development. Endocrinology, 153:6033-40 (2012).

  2. Tsunoda S, Kawano N, Miyado K, Kimura N, Fujii J. Impaired fertilizing ability of Sod1-deficient mouse sperm during in-vitro fertilization  Biology of Reproduction, 87(5):121 (2012).

  3. Ohnami N, Nakamura A, Miyado M, Sato M, Kawano N, Yoshida K, Harada Y, Takezawa Y, Kanai S, Ono C, Takahashi Y, Kimura K, Shida T, Miyado K, Umezawa A. CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte. Biology Open, 1:640-647 (2012) (Miyado K is a corresponding author).

  4. Takezawa Y, Yoshida K, Miyado K, Sato M, Nakamura A, Kawano N, Sakakibara K, Kondo T, Harada Y, Ohnami N, Kanai S, Miyado M, Saito H, Takahashi Y, Akutsu H, Umezawa A.  β-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion. Scientific Reports, Nature Publishing Group, 1: Article 68 (2011) (Miyado K is a corresponding author)

  5. 宮戸健二 テトラスパニンによる受精の膜融合制御 医学のあゆみ Vol.244, No.2, 181, 2013.

  6. 宮戸健二 卵由来エキソソームによる細胞融合の促進機構 医学のあゆみVol.241, No.11, 861-862, 2012.


No.23-41 海産無脊椎動物の受精機構に関わる新規遺伝子の遺伝学的探索
   代表研究者: 名古屋大学大学院理学系研究科附属臨海実験所 教授 澤田 均

  1. Yamaguchi, A., Saito, T., Yamada, L., Taniguchi, H., Harada, Y., and Sawada, H. (2011). Identification and localization of the sperm CRISP family protein CiUrabin involved in gamete interaction in the ascidian Ciona intestinalis. Mol. Reprod. Dev. 78, 488-497.

  2. Yokota, N., Kataoka, Y., Hashii, N., Kawasaki, N., and Sawada, H. (2011). Sperm-specific C-terminal processing of the proteasome PSMA1/α6 subunit. Mol. Reprod. Dev. 77, 640-647.

  3. Saito, T., Shiba, K., Inaba, K., Yamada, L., and Sawada, H. (2012). Self-incompatibility response induced by calcium increase in sperm of the ascidian Ciona intestinalis. Proc. Natl. Acad. Sci. U. S. A. 109, 4158-4162.

  4. Kawai, N., Ochiai, H., Sakuma, T., Yamada, L., Sawada, H., Yamamoto, T., and Sasakura, Y. (2012). Efficient target mutagenesis of the chordate Ciona intestinalis genome wth zinc-finger nucleases. Dev. Growth Differ., in press.


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